Advanced Osmium Redox Polymer Biosensors with Improved Enzyme Stability and Electron Transfer
발표자
신재호 (서울대학교 공과대학 재료공학부)
연구책임자
안철희 (서울대학교)
초록
내용
Self-monitoring of blood glucose (SMBG) via finger-prick sampling causes discomfort and offers only momentary glucose values. To overcome this, continuous glucose monitoring (CGM) biosensors have been developed, with enzyme-based systems offering high selectivity and sensitivity. While mediators like osmium (Os) complexes improve electrode stability, CGM still faces challenges in accuracy and long-term enzyme stability. To address this, we enhanced biosensor performance through Os complex modification and linker integration. Among tested complexes, the one with dmbpy ligands showed the lowest redox potential, improving electron transfer. Increasing the coordination number from four to five improved water solubility by preventing cross-linking. Ethylamine was introduced as a linker to covalently bind the polymer to the enzyme, strengthening interactions and enhancing current stability.