Molecularly Imprinted Sensors Based on Pyrrole and Pyrrole–Aniline Derivatives for Electrochemical Impedimetric Detection of 5-Fluorouracil
발표자
배정연 (경북대학교 고분자공학과)
연구책임자
박진영 (경북대학교)
초록
내용
5-Fluorouracil (5-FU) is an uracil-derived antitumor agent, and its overdose can lead to toxic metabolite accumulation and neurotoxicity. Therefore, sensitive and selective quantification of 5-FU is essential. To meet this analytical requirement, molecularly imprinted polymers (MIPs) have been studied as synthetic receptors for their selectivity, stability, and ease of preparation. Pyrrole is widely used as a functional monomer for electropolymerized MIP films due to its high conductivity, electroactivity, and processability. However, its limited functional groups restrict formation of specific interactions with target molecules. Therefore, in this study, 4-(1H-pyrrol-1-yl)aniline was introduced into the MIP matrix to enhance specific interactions with 5-FU by providing additional functional groups. To evaluate sensing performance of imprinted films, electrochemical impedance spectroscopy (EIS) was employed to measure changes in charge transfer resistance (Rct) upon 5-FU binding.