Near-Infrared mediated mesoporous silica-decorated upconversion nanoparticles for enhanced photodynamic and gas therapy
발표자
최종선 (충남대학교)
연구책임자
김소연 (충남대학교)
초록
내용
Mesoporous silica nanoparticles (MSNs) offer a versatile nanoplatform for the sustained release and encapsulation of various therapeutic agents, including photosensitizers (PS), anticancer drugs, and anti-inflammatory compounds. Due to their large specific surface area, high loading capacity, tunable pore size, and excellent biocompatibility, MSNs have been widely explored as potential nanocarriers in the biomedical field. Lanthanide-doped upconversion nanoparticles (UCNPs), which can absorb low-energy photons and emit high-energy photons, have emerged as a new class of fluorophores with advantages such as high photostability, narrow emission bands, low biotoxicity, and resistance to photobleaching. In this study, we developed mesoporous silica-coated multi-shell structured UCNPs (MUmS) co-loaded with a PS and a manganese carbonyl (MnCO) derivative for combined photodynamic and gas therapy under near-infrared (NIR) irradiation.