Optically tunable catalytic cancer therapy using enzyme-like chiral plasmonic nanoparticles
발표자
강하은 (이화여자대학교)
연구책임자
김동하 (이화여자대학교)
초록
내용
Cascade enzymatic reactions are key to complex biochemical processes but remain challenging to control in artificial systems. We report chiral plasmonic nanoparticles with glucose oxidase (GOD) and peroxidase (POD) activities for optically tunable catalytic cancer therapy. Using sequential circularly polarized light (RC then LC), we selectively activate GOD and POD, achieving 1.3× overall enhancement compared to uncontrolled cascades by optimizing the reaction environment. D-Au nanoparticles show 2× higher affinity for D-glucose due to chirality matching. In cell and mouse models, sequential irradiation yields the highest radical generation and best therapeutic efficacy. This platform offers strong potential for precision catalytic therapy.