Development of Phospholipid-based Nanostructures to Improve Cell Permeability of Nanopharmaceuticals
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Based on their tunable properties and possibility of surface modification, nanoparticles represent highly promising tools for drug delivery system. However, most of the nanoparticles enter cell via endocytosis and significant amount of the endocytosed cargos are degraded due to endosomal entrapment and lysosomal degradation. To overcome the limitations, we developed phospholipid-based nanodrill nanoparticle (LD-NPs) via self-assembly of phospholipids. LD-NPs were able to localize into cytoplasm of cells at 4 ℃ and endocytosis-inhibitors treated environments, revealing that LD-NPs could penetrate cells via energy-independent pathway through the membrane, unlike other nanoparticles. The potential of LD-NPs in drug delivery was confirmed through in vitro experiments, such as gene therapy and chemotherapy to drug resistance cells.