Chemistry of Polyphenols and Polydopamine for Biomedical Applications
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Catecholamines, present in nature in mussels, neurotransmitters, and various pigments, have attracted attention in materials science due to unique surface functionalization properties. Notable materials include poly(dopamine), poly(norepinephrine), and chitosan-catechol. The assembly of catecholamine is based on inter-molecular interactions known as cation-pi(a), leading to a novel self-sealing concept. These hierarchical assembly processes are reasonably predictable by understanding chemical structures of the defined building blocks and their interactions. However, biopigment assembly is rather fuzzy and unpredictable because a series of covalently coupled intermediates from catecholamine oxidation pathways progressively form a higher-level hierarchy. This study reports a different yet unexplored type of assembly process named “cation-pi progressive assembly.” We demonstrated for the first time that the cation-pi is the primary mechanism for intermolecular assembly in dopamine-melanin biopigment.1 Then, my talk will focus on blood vessel anastomosis using adhesive polyphenols. Suture-less alternatives exist, but the traditional method is still prevalent. A “less-suture” strategy, using thin, adhesive films, reduces stitches required in rat artery anastomosis from ten to four, saving time and alleviating fibrosis-mediated wall-thickening. This innovative approach offers solutions for emergency situations and small-diameter vessels, bridging material science with medical applications.2 (1) S. Hong, et al., Sci. Adv., 4, eaat7457 (2018). (2) J. Wu, et al., Adv. Mater., 2301098 (2023).