Design of Organic-inorganic Nanohybrids for Dynamic Biointerface Regulation(동적 바이오인터페이스 조절을 위한 유기-무기 나노복합체 개발)
발표자
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초록
내용
Cells dynamically interface with natural nanostructured extracellular matrix. Developing remotely manipulable organic-inorganic nanohybrids can dynamically display bioactive ligands or deliver functional molecules as a nanomedicine to regulate or unravel dynamic nanoscale interface between the cells and materials. In this talk, I will demonstrate the design of organic-inorganic nanohybrids that can be remotely controlled via various tissue-penetrative stimuli, such as magnetic field, light, self-assembling molecules, or their combinations.
In particular, I will show the magnetic field, light, or in situ self-assembly-based control for dynamic ligand presentation or molecular delivery. I will present their examples to regulate stem cell mechanotransduction and differentiation, macrophage polarization, and cancer cell apoptosis and ferroptosis. These strategies can offer benefits for safe and effective patient-tailorable therapies while minimizing their side effects.