Development of effective sonosensitizers exhibiting high biocompatibility and enhanced ROS generation
발표자
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초록
내용
Herein, we propose the Ir(Ⅲ)-based sonosensitizer conjugated with dendrimer to overcome the above problems. Our Ir(Ⅲ) complexes have various advantages such as high quantum yield, long lifetime, and high ROS generation. Additionally, we conjugate the dendrimer to Ir(Ⅲ) sonosensitizer for increasing biocompatibility. This Ir(Ⅲ) sensitizer conjugated dendrimer nanoparticle can form a spherical shape dendrimer micelle that can increase the water solubility of the nanoparticle and solve drug leakage problems. In addition, maleic anhydride introduced at the end of the dendrimer is separated from only the acidic cancer environment and converted into an amine, allowing nanoparticles to have a positive surface charge. Therefore, the cancer-targeting ability of these nanoparticles will increase and the therapeutic effect can be maximized.