Metalloprotein mimicking peptide fibrillar nanohybrids fabricated using nanoconfinement effects
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초록
내용
Tripeptides from metalloproteins exhibit potent anti-inflammatory properties, aiding wound healing in diverse organs. However, the instability of tripeptide-metal complexes in biological fluids poses challenges to their long-term and efficient use in physiology. To address this, we introduced a nanoconfinement effect within peptide nanoscaffolds through self-assembled peptide nanofibrils. This innovative approach organizes metal nanoparticles for enhanced colloidal stability. Integrating supplementary amino acid residues onto the fibrillar surface ensures robust complexes. Tripeptides on the peptide nanofibril surface induce lateral packing, symmetrically binding to adjacent Au ions, creating a linear hybrid structure with consistent Au nanoparticle spacing. This manufacturing strategy reinforces chemical and peptide structural bonds, yielding resilient bio-derived nanomaterials. .