Iodinated Nanoparticles as a Biodegradable CT Contrast Agent for Direct Imaging of Cerebral Thrombosis In Vivo
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초록
내용
Computed Tomography (CT) is widely used for imaging ischemic stroke due to its advantages such as penetration depth, fine resolution, and short operation time. Ischemic stroke arises when a blood clot obstructs a blood vessel supplying the brain. Existing contrast agents for CT scans can only reveal blood vessels, not the clot's precise size and shape. To obtain detailed information about the clot, MRI is required, but this method is costly and time-consuming. Therefore, we propose the use of iodinated organic nanoparticles as a biodegradable contrast agent for CT scans. A water-soluble iodinated monomer with a biodegradable linker was utilized for renal clearance and repeated administration. Imaging was successful showing not only the location but the size and shape of the clot as well, even for a partially obstructed blood vessel. In conclusion, we expect the iodinated nanoparticles will function as biodegradable CT contrast agents, enabling precise imaging of the clot's size and shape.