Polyvinylpyrrolidone -capped Inorganic Nanoparticles for Enhanced Cancer Radiotherapy
발표자
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초록
내용
Radiation therapy (RT) is an effective way to treat cancer, but it can damage surrounding normal tissue. Radiosensitizers have the potential to improve RT by increasing the radiosensitivity of tumor tissue and reducing toxicity to normal tissue. Nanomaterials with high atomic number can accumulate radiation through a variety of effects, increasing the production of reactive oxygen species (ROS), regulating the cell cycle, and inhibiting DNA repair, causing DNA damage and inducing cell death. In this study, we prepared nanoparticles using three metals (gold, gadolinium, and hafnium) and investigated their potential as radiosensitizers for cancer radiotherapy. Surface ligand exchange was performed using polyvinylpyrrolidone to impart biocompatibility and water dispersibility to the fabricated nanoparticles. Subsequently, upon irradiation, each nanoparticle generated more ROS and exhibited superior cancer cell killing effects compared to the control. In addition, the X-ray imaging property of inorganic nanoparticles was confirmed.