Multi-functional membrane for accelerated tendon regeneration and prevention of surrounding tissue adhesion
발표자
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초록
내용
Despite development of surgical techniques for tendon injury and advance in postoperative therapy regimens, insufficient regeneration of tendon and formation of restrictive tissue adhesions to regenerating tendon during the healing process are still a challenge for orthopedic surgeons. To overcome the problems, various strategies including delivery of cells/growth factors (to improved tendon regeneration); drug therapy, physical barrier, physical rehabilitation training (to prevent tissue adhesion) are intensively investigated. In this study, we developed a multi-functional membrane which can enhance tendon regeneration (by sustained release of PDGF-BB from unique leaf-stacked like structure; tissue regeneration layer) and prevent tissue adhesion (by physical separation of alginate between injured site and surrounding tissues; anti-tissue adhesion layer). The morphology, growth factor release behavior, cell adhesion, tenogenic differentiation and animal study (using rabbit tendon defect model) were investigated.