Local adaptation causes genetic changes in all organisms. These genetic changes occur over a long period of time and work in a state optimized for life in the environment. Some examples of local adaptation in human life include local zone and local environments such as climate, altitude, and disease. One of the characteristic genes relating to local adaptation in Asians is alcohol dehydrogenase (ADH) genes, which are found not only in humans but also in various organisms such as bacteria, amphibians, and birds. In this study, by employing molecular dynamics simulation and network theory, we investigate the molecular evolution of ADH enzymes for Saccharomyces Cerevisiae,Gadus Morhua, and Homo Sapiens.