Combinatorial wound healing using skin-adhesive nanofibers equipped with LED patches for photobiomodulation
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초록
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Recent advancements in photomedicine technology have led to the successful use of safe and non-invasive photobiomodulation for wound healing. In this study, we present a novel approach to wound healing by combining flexible nanofibrous membranes and light-emitting diode (LED) arrays to distribute light sources fully onto the entire damaged skin area. We used hyaluronic acid (HA)-crosslinked gelatin nanofibrous fabric (HA/Gel) with a catechol moiety via electrospinning to prepare the adhesive membrane material, which can prevent fluid loss through exudation during the healing process. Furthermore, we introduced wearable LED patches into the nanofibrous membrane, capable of emitting near-infrared light to accelerate healing by increasing blood flow, reducing inflammation, and promoting the growth of new tissue. By using this combinatorial approach, our results show that wounds treated with this approach have faster healing compared to those treated with nanofibers or LED patches alone.