Upconversion-based photodynamic therapy synergized with an immune checkpoint inhibitor for enhanced cancer treatment
발표자
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초록
내용
Lanthanide-doped upconversion nanoparticles (UCNPs) have the unique phenomenon of anti-Stokes capable of converting low-energy NIR to high-energy light such as ultraviolet and visible light. These optical properties of UCNPs can breakthrough in photodynamic therapy (PDT) which has a low penetration depth of photosensitizer (PS). Particularly, combining PDT with specific immunotherapy can not only enhance the antitumor immune response by immunogenic cell death but also activate the immune system to induce the promotion of T cells, resulting in inhibited tumor growth. In this study, multi-shell structured UCNPs modified with the PS and immune checkpoint inhibitor were prepared for combined PDT and cancer immunotherapy. In addition, the anti-tumor efficacy of combined PDT and cancer immunotherapy with the multi-shell structured UCNP-based nanocarriers were investigated in vitro and in vivo.