Chitosan and (Phenylthio) acetic acid-based ion pair for temperature and oxidation-responsive drug release
발표자
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초록
내용
Chitosan (CTSN), a cationic biopolymer was used to prepare Ion pair self-assembly (IPSAM)with (phenylthio)acetic acid (PTA) as hydrophobic counter ion which is responsive to temperature and oxidation . CTSN/PTA IPSAM was found as sphere-like nanoparticles whose diameter was 30-50 nm on TEM micrograph. The ionic interaction between CTSN and PTA and the oxidation of PTA were confirmed by FT-IR spectroscopy. The release of payload (i.e. Nile red) in IPSAM was restrained below the UCST but it was triggered above the phase transition temperature possibly due to the disintegration of the IPSAM and PTA oxidation. The release was found to be higher in tumor environment temperature in the presence of H2O2 indicating the release was dependent on temperature and oxidation.