Oxidation/temperature responsive dioleoylphosphatidylethanolamine liposome containing polyethyleneimine/4-(Methylthio)phenylacetic acid ion pair
발표자
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초록
내용
Temperature and oxidation sensitive liposome was prepared by using poly (ethylenemine) (PEI) / 4- (Methylthiao) phenylacetic acid (MTPA) ion pair to stabilize the dioleoylphysidylethanolamine (DOPE) bilayers. The behavior of UCST can be observed in PEI/MTPA ion pair and decreased as the concentration of hydrogen peroxide(H2O2) increased. And PEI/MTPA ion pair was confirmed to self-assemble into nanospheres(IPSAM) in transmission electron microscopy images. The results of FT-IR and 1H-NMR showed the formation of salt bridges and proton peak shift due to the interaction between amino and carboxyl groups. PTA in ion pair was confirmed to be oxidized by H2O2 through XPS results. In addition, due to the amphiphilic property of ion pair, DOPE liposome bilayer can be stabilized by ion pair. And liposomes released its payload in the form of temperature and oxidative response.