Oral drug delivery strategy via bile acid decorated nanoparticle lymphatic transport
발표자
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초록
내용
Herein, we describe orally administrable bile acid-decorated nanoparticles (BDN) for non-invasive drug administration. This study showed that BDN can be taken up in the distal ileum via the apical sodium-dependent bile acid transporter and transported to the lymphatic circulation via the chylomicron pathway. BDN with insulin and exenatide-4 has shown promise in treating type 1 and type 2 diabetes, respectively, and BDN with docetaxel has been demonstrated to be effective against various tumors. BDN can also be delivered directly to lymph nodes for tumor immunotherapy. The combination of BA recycling and fat absorption mechanisms provided a non-invasive means of delivering nanomedicine to the central lymphatic system, bypassing hepatic and intestinal first-pass metabolism. This approach enhances the therapeutic efficacy of BDN, making it a promising candidate for targeted treatment of diseases such as cancer and diabetes.