Fabrication and Characterization of a Powder-Type Anti-Adhesion Agent with Improved Tissue Adhesiveness
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초록
내용
Formation of post-surgical adhesions of fibrous bands between organs and tissues causes symptomatic diseases. For adhesion prevention, the use of barrier materials to separate the injury site and organs has been accepted as the optimized strategy. In this study, the powder-type anti-adhesion agent made of hyaluronic acid (HA) and poly(vinyl pyrrolidone) (PVP) was fabricated and evaluated to investigate the tissue adhesion prevention using rat peritoneum/cecum defect model. HA is a promising material because of its biocompatibility. But its weak mechanical strength still remains significant challenge. To overcome these disadvantages, PVP was added to form semi-IPN structure to improve the residence stability of the HA in the body and adding PVP can enhance the residence tackiness. In vivo animal test, x-HA/PVP powder showed an excellent anti-adhesion. Crosslinking the HA/PVP powder can be proposed as a useful approach to reduce undesired postoperative tissue adhesion.