Hyaluronate-Black Phosphorus-Upconversion Nanoparticles Complexor Multi-Modal Theranosis of Skin Cancer
발표자
()
초록
내용
Black phosphorus (BP) has been widely investigated for various biomedical applications with the unique characteristics of 2D nanomaterials. However, the finite depth of light penetration has limited further development of BP-based photomedicines. In this regard, we developed hyaluronate-BP-upconversion nanoparticle (HA-BP-UCNP) complex for near-infrared (NIR) light mediated multimodal theranosis of skin cancer with photoacoustic (PA) bioimaging, photodynamic therapy (PDT), and photothermal therapy (PTT). In contrast to the conventional BP-based cancer theranosis systems, HA-BP-UCNP could be non-invasively delivered into the tumor site to induce the tumor apoptosis upon NIR. HA in the complex facilitated the transdermal delivery. Upon NIR, UCNP converted the light to UV-blue light to generate ROS by sensitizing BP in the complex for PDT, and NIR also triggered PTT. We demonstrate the feasibility with in vitro, in vivo test.