Reinforced Gelatin-Methacrylate Hydrogels Containing Nanofiber Fragments for 3D Bioprinting
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초록
내용
In general, tissue engineering deals with cells, scaffolds, and growth factors. The scaffold in the form of a hydrogel facilitates retention of abundant moisture and nutrients while transporting metabolic waste through diffusion and rapid biodegradation. 3D printing of the additive manufacturing method can precisely control the external dimensions, internal pore shape and size of the scaffold structure with high reproducibility. Bio-ink has a disadvantage that it cannot be stacked in a 3D structure in a desired shape, and various materials have been considered to solve this problem. We used poly(lactic-co-glycolic acid) nanofiber fragments (PLGA-NF) as an artificial extracellular matrix in gelMA hydrogels and applied to 3D bioprinting. The critical advantage of the gelMA bioink containing PLGA-NF is compromising structural stability and cell proliferation by incorporating solid fragments for a cell-laden 3D scaffold construct.