Biomaterial-mediated Membrane Decoration for Augmenting Immune Synapse Interaction of Natural Killer cells in Cancer Immunotherapy
발표자
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초록
내용
Suitable modulation of immune cell surface membranes could augment the recognition of target cancer cells via surface-dependent immune synapse interactions. By facilitating dynamics of receptor-ligand interactions in immune synapse, infused immune cells are able to recognize target tumor cell population, and thereby enhanced anticancer efficacy of surface-engineered natural killer (NK) cells and subsequent tumor suppression are successfully achieved. In this research, biomaterial-mediated ex vivo cell surface engineering techniques are introduced for the membrane decoration of cancer-targeting moieties on NK cells. Upon, a variety of design strategies of membrane-presentable modules have been developed to improve anticancer functions of surface-engineered NK cells by anchoring lipid conjugate biomaterials onto NK cell surfaces via hydrophobic interaction.