Polydopamine Materials for Empowering Cancer Immunotherapy
발표자
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초록
내용
In immunotherapy, stimulating T cells ex vivo requires substantial resources. Our study introduces a novel approach using polydopamine-coated DNA microflowers (DM) to mimic dendritic cells and program on-site T cell stimulation. These microflowers, modified with anti-CD3 and anti-CD28 antibodies, efficiently trap the T cell-stimulating cytokine, creating interleukin-2-loaded DM-A (DM-AI). Compared to polystyrene microparticles, DM-AI showed significantly enhanced interaction with T cell surfaces, resulting in highly effective ex vivo expansion of cytotoxic T cells. Additionally, local injection of DM-AI into tumor tissues promoted recruitment and expansion of cytotoxic T cells. Remarkably, model animals treated with DM-AI did not experience primary tumor growth and were protected from rechallenged distant tumor growth, indicating promising potential for immunotherapy.