Development of glycol chitosan-based quaternary ammonium derivatives with non-cytotoxic and excellent antimicrobial effects
발표자
()
초록
내용
Bacterial infections range from relatively simple ailments to severe and life-threatening conditions, such as pneumonia, urinary tract infections, sepsis, and more. Antibiotics are essential medications used to treat these infections. As novel antimicrobial agents, we synthesized glycol chitosan-based quaternary ammonium materials through aza-Michael reactions between glycol chitosan and various quaternary ammonium salts with different hydrocarbon chain lengths. The four different derivatives were synthesized and characterized by 1H NMR spectroscopy. The antimicrobial effects and cytotoxicity of the derivatives were examined through the colony forming unit method and CCK-8 assay, demonstrating that the materials with specific hydrocarbon chain length exhibit non-cytotoxic and excellent antimicrobial properties. We believe that the quaternary ammonium derivative has high potential in treating healthcare-associated bacterial infections.