Hemocompatible and Antibacterial Coating Using the Complexation of <em>o</em>-Carboxymethyl Chitosan and Zirconium(IV) ions
발표자
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초록
내용
This study introduces a novel antibacterial coating using o-carboxymethyl chitosan (CMC) complexed with zirconium chloride (ZrCl4) in a single step. CMC is a derivative of chitosan, a natural biopolymer, and possesses valuable properties such as biocompatibility, antimicrobial activity, and non-cytotoxicity, making CMC highly desirable for various applications in biomedical fields. CMC was explored at various concentrations (1, 2, 4, 8, and 16 mg/mL) by forming coordination bonds with Zr4+ ions to optimize the coating conditions. The optimal coating conditions could be also applied to titanium dioxide and gold. The CMC/Zr4+ coatings were characterized by contact angle goniometry, ellipsometry, and X-ray photoelectron spectroscopy. The CMC/Zr4+-coatings exhibited the excellent antibacterial effects, inhibiting bacterial adhesion. Moreover, the hemocompatibility of the CMC/Zr4+ coatings will be presented by using antiplatelet and enzyme-linked immunosorbent assays.