Synthesis of carboxylated glycol chitosan derivative and its inhibitory effects on platelet and bacterial surface adhesion
발표자
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초록
내용
In medicine, biofouling refers to the nonspecific adsorption of organisms such as platelet and bacteria on the surface of medical devices that come into contact with or are inserted into the human body. It degrades the performance of medical devices and adversely affects the healing process through implanted biomaterials. In addition, the formation of biofilms, which are created by the adhesion and accumulation of microorganisms to surfaces, significantly contributes to infections associated with medical devices. To inhibit such biofouling and associated infections, we synthesized a carboxylated derivative of glycol chitosan and developed a facile yet effective antifouling coating. The carboxylated glycol chitosan coatings showed excellent antiplatelet and antibacterial properties compared to controls. The current approach can even be applied to stents, proving that its potential as a biomaterial to inhibit infection in medical devices.