Immune Designer for Dynamic Tailoring of Innate Immunity
발표자
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초록
내용
Although conventional innate immune stimuli contribute to immune activation, they induce exhausted immune cells, resulting in suboptimal cancer immunotherapy. Rationally designed immunomodulatory materials can induce potent and persistent immune responses with reduced exhaustion and minimized immune-related toxicities. Recently, a novel type of immunomodulatory system which integrated innate stimuli in the context of time, order, and duration was developed. I would like to discuss the prospects of it as a next-generation immune designer, which can provide design strategy for synchronous and dynamic tailoring of innate immunity for enhanced cancer immunotherapy as well as protective immunity against infectious pathogens.