Long-Term Stable Wireless Smart Contact Lens for Robust Digital Diabetes Diagnosis
발표자
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초록
내용
Digital continuous glucose monitoring (CGM) with wearable devices have attracted great attention as a new paradigm medical device for diabetes management. However, the relatively inaccurate performance and instability of CGM devices have limited their wide applications in the clinic. Here, we developed hyaluronate (HA) modified Au@Pt bimetallic electrodes for long-term stable and accurate CGM of smart contact lens. After glucose oxidation, the bimetallic electrodes facilitated the rapid decomposition of hydrogen peroxide and charge transfer for robust CGM. The dissolution of Au electrode by chloride ion in tears was prevented by passivating the Au@Pt bimetallic electrode with branch-group thiolated HA. In diabetic and normal rabbits, the smart contact lens with HA-Au@Pt bimetallic electrodes had a high correlation (ρ = 0.875) CGM with 98.6 % clinically acceptable data for 3 weeks. Taken together, the smart contact lens with long-term stable HA-Au/Pt bimetallic electrodes will pave to the clinical applications of long-term CGMs.