Zwitterionic Surfaces for Inhibition of Pathogenic Immune Responses
발표자
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초록
내용
Zwitterionic polymers containing neighboring positive and negative charges in their side chains have a much stronger hydrophilicity based on ionic solvation compared to other non-ionic polymers that rely on hydrogen bonding for water binding. Resultantly, they exhibit outstanding anti-biofouling property and have been highlighted as next-generation coating materials for biomedical applications.
In this presentation, the grafting effect of 2-methacryloyloxylethyl phosphorylcholine (MPC)-based polymer, a representative zwitterionic polymer, on the immune responses will be reported. MPC grafting showed outstanding inhibitory effect against inflammation-related excessive fibrous capsule formation around silicone breast implants in rats and pigs. Furthermore, MPC grafting could inhibit induction and progression of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), which is suspected be initiated by bacteria-driven immune responses around the implants.