Polysorbate-based drug carriers for mitochondria-targeted sonodynamic cancer therapy
발표자
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초록
내용
Sonodynamic therapy (SDT) is a non-invasive therapeutic modality that can eradicate deep-seated tumors under ultrasound (US) irradiation while minimizing damage to surrounding normal tissues. In this study, polysorbate (Tween80) was formulated as a safe nanocarrier to deliver mitochondria-targeting sonosensitizer [triphenylphosphonium-conjugated chlorin e6 (TPP-Ce6)] and a cancer-specific chemotherapeutic agent, piperlongumine (PL), to cancer cells. The TPP conjugation of Ce6 significantly increased the mitochondrial accumulation. In addition, Tween80-based nanocarriers significantly enhanced the cellular uptake of TPP-Ce6 in cancer cells. After cellular internalization, TPP-Ce6 triggered the generation of intracellular reactive oxygen species (ROS) upon US exposure. In addition, PL also improved the SDT effectiveness by producing an excessive amount of ROS. The combined effect of mitochondria-targeted SDT and cancer-selective apoptosis by TPP-Ce6- and PL-loaded Tween80 nanocarriers was demonstrated in vitro.