Synthesis of Inorganic Structures Mimicking Specific Protein Assemblies in Multicellular Organisms via Antibody-Guided Biotemplating
발표자
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초록
내용
Biological systems are highly integrated, with each part designed for specific functions. These diverse functionalities arise from hierarchical biological structures. To exploit such complex biological structures, the mineralization of biostructures has gained popularity, called biotemplating. Nevertheless, using specific proteins as templates has only been demonstrated in simple organisms. Herein, we propose a method for synthesizing metallic structures that imitate specific protein assemblies in mammalian cells, tissues, and extracellular matrix for the first time. We introduced 1.4-nm nanogold-conjugated antibodies and labeled them to a specific protein, and the nanogold then acted as the nucleation sites. The synthesized biocomposites were used in catalysts for liquid phase reactions and hydrogen evolution reaction, and hydrogen sensing. Furthermore, we employed the specific protein structures within mouse organs as scaffolds to extend the scope of our method.