Hydrogen Sulfide Detection Induced Burst Release of Model Drug From Polymeric Micelles
발표자
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초록
내용
Recently, several illnesses, including cancer, cirrhosis of the liver, salmonellosis, Alzheimer's disease, and pathological insulin production, have been associated with aberrant concentrations of H2S. Passerini multicomponent polymerization (PMCP) is simple and uncomplicated polymerization which can produce complex soft materials in a single pot using well-defined, structurally diverse polymers allowing the safe administration of medicinal drugs to specified regions. In this study, a PMCP reaction of a H2S-specific unit (designated M1) and 6-isocyanohexanoic acid is performed in the presence of polyethylene glycol (PEG) dicarboxylic acid as the chain transfer agent to yield a smart poly(ester-amide)-based amphiphilic polymer, named P1. Upon the exposure of H2S to a P1 micelle solution encapsulating the hydrophobic model drug, rhodamine, then resulting in the swelling of the micelles and the abrupt release of rhodamine.