Antimicrobial peptoid as a photo-crosslinker for gelatin hydrogel
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초록
내용
Antimicrobial peptoid (N-substituted glycine oligomer) as a mimic of antimicrobial peptides (AMPs) has been widely studied as a promising candidate for inhibition and treatment of microbial infections. In addition, peptoid has advantages such as biocompatibility, free rotation, enzymatic stability, which are suitable for biomedical materials. Herein, we employed an antimicrobial peptoid as a photo-crosslinker for gelatin-based hydrogels to introduce antimicrobial activity. The cross-linking between peptoids and gelatin networks was achieved through thiol-ene click chemistry. We studied the gelation tendency of hydrogels in a sol-gel-sol manner depending on the concentration of peptoid cross-linker. Their antimicrobial activity was confirmed against Gram-positive bacteria (i.e., Staphylococcus aureus) by Live/Dead assay. Our findings can provide an insight into peptoid-based hydrogels as materials for wound dressing.