Effect of PLLA and Gelatin Content on Mechanical Properties and Cytotoxicity of PLLA/Gelatin Hybrid Polymer Membrane
발표자
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초록
내용
PLLA and PLLA/gelatin membranes were prepared to evaluate the potential of the membranes as absorbable periodontal regeneration. The optimum PLLA composition of the membrane was 3wt%. The tensile strength and WUC of PLLA/gelatin membrane increased from 9.1±0.9MPa to 13.3±2.3MPa and from 329% to 1248%, respectively, as the gelatin content increased from 0wt% to 40wt%. However, the strain dramatically decreased from 3.0 to 0.5. Commercial membranes were used wet. Wet stress and strain of PLLA/gelatin membranes in water decreased from 13.3±2.3 MPa to 6.3±0.3 MPa and increased from 0.5 to 2.1, respectively, as the gelatin was blended with PLLA at 40 wt%. The biodegradation rate of the PLLA/gelatin blend increased to 38% as the gelatin content increased to 40%. The L-929 and MG-63 cell viability of the PLLA/gelatin membranes was always above 95%. Experimental results suggested that the tunable PLLA/gelatin hybrid membrane was suited for periodontal tissue regeneration.