Catalase mimicking manganese oxide nanozymes as anti-cancer and anti-inflammation nanotherapeutics
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초록
내용
Biocompatible catalytic nanoparticles are recently investigated for advanced nano-therapeutics as they mimic enzyme-like activities such as peroxidase-like, oxidase-like, catalase-like, and superoxide dismutase (SOD)-like activities. Manganese oxide nanoparticles are highly efficient catalase-mimicking nanoparticles. Manganese oxide nanoparticles quickly react with H2O2 and release oxygen and water as the byproducts. Site-specific oxygen production properties of manganese nanoparticles can be beneficial to treat hypoxic tumors where oxygen levels are extremely low. In addition, peroxide scavenging is one of the major advantages to reduce excessive oxidative stress in inflammatory diseases. To exploit these properties for therapeutic purposes, we have developed different types of manganese oxide nanoformulations. Taken together, manganese oxide nanoparticles are potential therapeutic options to investigate pre-clinical and clinical stages for the treatment of multiple inflammatory diseases and cancers.