Nitric oxide donor/scavenger for the treatment of various disease
발표자
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초록
내용
In this study, we report the design of a multifunctional system comprised of NO-releasing BNN6 and piezoelectric BTNP coated with polydopamine. We investigated the ultrasound-responsive NO-releasing profile of the nanoparticle and its NO-mediated BBB opening, as well as the mechanism of BBB opening by NO. We show that the piezoelectric nanoparticles can alleviate the symptoms of Parkinson’s disease in the animals. Herein, we also report the rational design of an injectable in situ polymeric aggregate-embodied hybrid NO-scavenging and sequential drug-releasing gel platform for the combinatorial treatment of rheumatoid arthritis (RA) by incorporating a “clickable” NO-cleavable cross-linker. Consecutive NO-scavenging action reduces pro-inflammatory cytokine levels in LPS-stimulated macrophage cell lines in vitro. Finally, the intra-articularly injected M-NO gel with anti-inflammatory dexamethasone significantly alleviated the symptoms of RA, with negligible toxicity, in animal models.