Exploring the Frontiers of Polymer Science and Technology: From Fundamentals to Applications (English)
발표 구분
초청강연
제목
Scaling Relationship of Complex Coacervate Core Micelles
발표자
()
초록
내용
Complex coacervate core micelles (C3Ms) formed by mixing two oppositely charged block copolyelectrolyte solutions have been widely employed as delivery vehicles of biological and pharmaceutical molecules. Despite extensive experimentation on the structure and properties of C3Ms, much less is known about the relationship between the C3M structure and the molecular/environmental design, which is crucial to predict and design the C3Ms for enhanced transportation and cellular uptake efficiency. In this study, we present small-angle neutron and X-ray scattering (SAN/XS) measurements on the AB + AC system and propose a scaling theory to quantify and understand the relationship between the C3M structure and the molecular design. Although the corona block is significantly longer than the core block, a highly swollen core by water enables the core blocks to be stretched significantly and corona chains to be minimally overlapped.