Antioxidant Impact of Polyphenol on Cytoskeletal Network Remodeling of Cancer cells and Intracellular Imaging
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Natural phenolic compounds have antioxidant properties owing to their free radical-scavenging capability. Herein, we revealed that the number of phenolic hydroxyl groups in phenolics played a central role in their antioxidant capacity. Based on the finding, tannic acid showed the most effective antioxidant potential, e.g., 76% in tannic acid versus 22% in vitamin C as a standard antioxidant component. Because cancer progression is closely related to oxidative processes at the cellular level, we further applied the surface treatment of tannic acid drug-delivery nanocarriers. Tannic acid-loaded nanocarriers reduced reactive oxygen species of cancer cells as much as 41% of vehicle treatment and remodeled cytoskeletal network than vehicle-treated cells, implying a potential of blocking invasiveness of cancer cells.