Inhibition of Ice Recrystallization by Dendritic Polyglycerols
발표자
()
초록
내용
Antifreeze proteins protect organisms from freezing damage by inhibiting ice formation. Ice recrystallization inhibition (IRI) of various small molecules and polymers has been extensively investigated. In our previous research, we demonstrated the effect of branching degree on ice formation behavior including hyperbranched and linear polyglycerols. In this study, we synthesized dendritic polyglycerols (dPGs) with different generations (dPG-1, dPG-2, dPG-3, and dPG-4) and evaluated their IRI activity in biological buffer systems. Interestingly, these results showed that IRI activity of dPGs increased with increasing generation. Additionally, we investigated the ice growth rate of dPGs through molecular dynamic simulations. Finally, cryopreservation using dPG-4 exhibited a superior performance compared to the conventional 10% DMSO solution.