Development of an Anisotropic Fibrous Embedded Hydrogel Matrix implementing Architecture and Characteristics of Vascular Tissue
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The growing need to develop biomaterials with enhanced bio-compatibility and human tissue-like characteristics has driven research towards innovative solutions for biomedical applications. A key challenge faced by current biomedical materials is their mechanical mismatch with native tissues, specifically the 'strain-stiffening effect,' which results in progressive stiffening of biological tissues under increased strain. To tackle this issue, this study introduces the development of an anisotropic fibrous embedded hydrogel matrix, incorporating anisotropic electrospun mesh within the hydrogel to effectively address the structural organization of human tissue. This advancement shows promising potential for improving tissue engineering techniques and biomedical applications, including organ implantation and flexible sensors, thereby contributing significantly to the advancement of regenerative medicine and healthcare technology.