Direct visualization of molecular chirality using achiral liquid crystal
발표자
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초록
내용
In the pharmaceutical industry, more than 50% of the drugs are homochiral materials. To prevent drug misuse, it is crucial to distinguish fatal toxicity depending on their enantiomeric excess. However, conventional organic streoisomer cannot be easily detected by general methods. In this study, we suggest new methods for detecting enantiomeric excess directly with achiral liquid crystal (LC) materials. The first method is to detect chirality using racemic structures formed with lyotropic chromonic LCs. The LC sturctures are transformed when chiral materials are added to racemic LC structures. The second method is to use an achiral LC film that has color variations depending on the incident polarization of the light. When linearly polarized light passes through the chiral solution and then through the film, different colors are detected according to the chirality of solution. These methods can visualize enantiomeric excess by the naked eye or by a simple polarizing microscope.