A long-term controlled antibacterial drug delivery systems from diverse morphology of porous poly(lactic acid) fibers
발표자
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초록
내용
The porous PLA fibers have high surface to volume ratio, small fiber average diameter, and high nanoscale porosity. These high surface to volume ratio and nanoscale porosity result in controlled release of antimicrobial agents. The aim of this study was to fabricate various morphology of porous PLA fiber and control the release of antibacterial agents. Antimicrobial agents-loaded to porous PLA fibers were evaluated antibacterial activities using three types of antibacterial assays (inhibition zone tests, live/dead bacterial cell assays and antibacterial kinetic growth assays) against E. coli and S. epidermidis. For the results, we found that antibacterial performance was as follows gentamicin ＞ amikacin＞kanamycin ＞TMC ＞chitosan and more efficient on S. epidermidis than E. coli. It has been found that nonporous PLA fibers exhibits the initial-burst release profile whereas porous PLA fibers with highly porosity or deep-depth pores indicate a steady release.