Combination of Electrical Ablation and Functional Nanoparticle for <EM>In Situ</EM> Cancer Vaccination
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초록
내용
Cancer immunotherapy is a cutting-edge treatment that employs immune system components to combat cancer. Electrical ablation (EA) is a newly developed tumor treatment approach that uses pulsed electronic fields to trigger apoptotic cell death in cancer cells without utilizing thermal energy. The EA can cause cancer associated antigens and damage-associated molecular patterns (DAMPs) to be produced, which can trigger anti-cancer immune responses. We established a new in situ cancer vaccination technique for better cancer treatment efficacy using a combination of EA and functional nanoparticle coupled with immune adjuvant in this work. The synergistic effect of EA with functional nanoparticle dramatically increases anti-cancer immune responses, according to in vitro and in vivo tests. Overall, we believe that the unique in situ vaccination of EA with functional nanoparticle offers a lot of promise for treating numerous incurable cancers.