Development of safe and efficient lipid nanoparticles (LNP) including biodegradable ionizable lipid
발표자
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초록
내용
The development of vaccine has become a hot topic during the Pandemic of SARS-COV-2. In particular, mRNA vaccines and lipid nanoparticles that deliver mRNA are actively under investigation. Lipid nanoparticle (LNP) technology has been widely used as a delivery platform to facilitate the delivery of mRNA to target tissues or cells. However, the ionizable lipids developed in the early days had a toxicity issue due to its long half-life. Here, we have synthesized and developed an ionizable lipid (EZ4) containing biodegradable functional groups to lower the toxicity. EZ4 showed a good transfection efficiency to strongly express target protein compared to conventional ionizable lipids when injected through intravenously (IV) and/or intramuscularly (IM). Moreover, it showed low toxicity both in vitro and in vivo. EZ4 has shown great potential for the development of new generation of biodegradable ionizable lipids.