Cell barrier layer integrity measurement by printed OECT based on PEDOT:PSS
발표자
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초록
내용
Electrical impedance sensing of biological systems, especially cultured epithelial cell layers, is now a common technique to monitor cell morphology, and cell layer/tissue integrity. Existing methods to measure electrical impdedance most often rely on a two electrode configuration, where low frequency signals are challenging to obtain for small devices and for tissues with high resistance, due to low current. Organic electrochemical transistors(OECTs) have been shown to efficiently transduce and amplify low-level ionic fluxes in biological systems into electronic output signals. Here we present the how to measure the transepithelial/transendothelial electrical resistance(TEER) by OECT. In this work, we optimized fabrication of inkjet-printed OECTs and measure the cell barrier layer integrity by OECTs. This results will improve the characteristics of OECT devices to make them suitable for use in bioelectronics.