Prodrug Blend Thermogel as a Safe and Effective Injectable Formulation for Inner Ear Drug Delivery
발표자
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초록
내용
The safe and effective delivery of therapeutic drugs to inner ear remains an unmet clinical need. In this study, we developed a new prodrug blend thermogel with high drug loading and controlled release capacities. The blend thermogel was prepared by physical mixing of hexanoyl glycol chitosan (HGC) as a thermogel component and dexamethasone conjugated glycol chitosan (GC-DEX) as a prodrug component. The chemical composition and drug loading content of blend thermogels could be easily modulated by varying the mixing ratio of HGC to GC-DEX and their physicochemical properties were evaluated for injectable formulation application. The blend thermogels showed a modulated sol-gel transition behavior with useful rheological properties and a sustained release compared to free DEX with or without HGC. Consequently, our prodrug thermogel system could be promising as a new injectable delivery formulation to biocompatibility, biodegradability, thermo-gelation, and controlled release.