Electrospun 3D Keratin Nanofiber Membranes: A unique Architecture for Biomedical Applications
발표자
()
초록
내용
This study presents a novel scaffold made of electrospun keratin nanofibers with three-dimensional (3D) fiber networks through the use of post-electrospinning treatment based on a gas-forming technique. The 3D assembly of biocompatible keratin and polyvinyl alcohol (PVA) could more closely mimic the native structure of the extracellular matrix (ECM). The transparency and mechanical properties of the 3D keratin/PVA NFs membrane were highly enhanced as compared to its 2D counterpart, which is mainly due to its unique 3D fiber orientation. The biocompatibility of the 3D membrane was studied using fibroblast cells and it showed excellent performance without any toxic behavior. Easy fabrication, excellent mechanical and biocompatible properties indicate significant promise of this material for a variety of potential applications in biomedical applications.