Artificial cell penetrating polypeptide for mitochondria disruption in cancer starvation therapy
발표자
()
초록
내용
Cancer metabolic abnormalities have long been recognized as a promising target for cancer therapy. Inhibition of a single metabolic route, on the other hand, is ineffective. Therefore, a technique for inhibiting tumor glycolysis and oxidative phosphorylation at the same time is proposed in this work. An antiglycolytic drug and a chemically synthesized mitochondria-targeting polypeptide were concurrently used to effectively exhaust cancer cells' energy supply, resulting in a synergetic effect in cancer starvation treatment. The mechanism and proof of the cooperative impact of this combinatorial strategy were demonstrated in vitro. This work looks forward to bringing novel insights in cancer starvation therapies by blocking numerous metabolic processes.