Preparation and Characterization of Blend Thermogel System for Biomedical Applications
발표자
()
초록
내용
Although thermogelling biomaterials have great potential for use in diverse biomedical applications, their applications and performance have been limited by their inherent deficient characteristics, such as poor physical and mechanical properties and the difficulty in tailor-making their properties for specific applications. In this study, a series of blend thermogels have been prepared by physical mixing of two thermogels, PEO-PPO-PEO triblock copolymer as a representative synthetic thermogel, and hexanoyl glycol chitosan (HGC) as a new class of polysaccharide thermogel. Various blend thermogels have been characterized and compared in terms of thermogelation, rheological properties, physical stability, and degradability. Our blend thermogel system could not only customize the sol-gel transition temperature but also demonstrate modulated physico-mechanical properties, allowing thermogels to extend their potential biomedical applications with enhanced performance.