Injectable microsphere/thermogel hybrid formulation system for intratympanic delivery of dexamethasone
발표자
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초록
내용
Since conventional strategies for inner ear drug delivery accompany side effects and limited delivery and absorption efficiencies, there has been continuous need to develop a new safe and effective local delivery system. In this study, a new injectable microsphere-thermogel hybrid system has been developed for efficient inner ear delivery of dexamethasone. The biocompatible and biodegradable hexanoyl glycol chitosan (HGC) was synthesized and evaluated as an injectable thermogel carrier for local delivery of dexamethasone (DEX) or DEX encapsulated poly(D,L-lactide) microsphere via intratympanic injection. The hybrid system demonstrated physicochemical and rheological properties suitable for injectable formulation and a sustained drug release for more than one month without any initial burst release. Therefore, our injectable hybrid system could be promising for efficient delivery of DEX into inner ear.